Journal article
Interactive relationships of Type 2 diabetes and bipolar disorder with cognition: evidence of putative premature cognitive ageing in the UK Biobank Cohort
Elysha Ringin, David W Dunstan, Roger S McIntyre, Michael Berk, Neville Owen, Susan L Rossell, Tamsyn E Van Rheenen
NEUROPSYCHOPHARMACOLOGY | SPRINGERNATURE | Published : 2023
Abstract
Type 2 diabetes (T2D) is disproportionately prevalent in bipolar disorder (BD) and is associated with cognitive deficits in psychiatrically healthy cohorts. Whether there is an interaction effect between T2D and BD on cognition remains unclear. Using the UK Biobank, we explored interactions between T2D, BD and cognition during mid and later life; and examined age-related cognitive performance effects in BD as a function of T2D. Data were available for 1511 participants with BD (85 T2D), and 81,162 psychiatrically healthy comparisons (HC) (3430 T2D). BD and T2D status were determined by validated measures created specifically for the UK Biobank. Diagnostic and age-related associations between..
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Awarded by National Health and Medical Research Council (NHMRC) Early Career Fellowship
Awarded by NHMRC Senior Principal Research Fellowships
Funding Acknowledgements
The authors would like to acknowledge financial support (unrelated to the current paper) from Club Melbourne, the Henry Freeman Trust, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L Cooper Foundation, and the Society of Mental Health Research. Dr Van Rheenen was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (GNT1088785) and a Dame Kate Campbell Fellowship from the University of Melbourne. Professor Berk (GNT1156072), Professor Owen (GNT1003960), Professor Rossell (GNT1154651), and Professor Dunstan (GNT1078360) were supported by a NHMRC Senior Principal Research Fellowships. Professor Owen was additionally supported by the Victorian Government's Operational Infrastructure Support Program. None of the funding sources played any role in the analysis, or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Open Access funding enabled and organized by CAUL and its Member Institutions.